Parkinson's Disease: Molecular Risk Factors
23 slide(s) – 00:17:19 – English – 2011-11-12
Parkinson\'s disease (PD) is a progressive neurodegenerative disorder second most common after Alzheimer´s disease. Diagnosis remains clinical, based on phenotypic patterns. In the last decay many attempt in developing early differential pre-clinical markers were reported. Here, the molecular risk factors that may link between the etiopathogenesis leading to PD and peripheral markers will be discussed. Genetic variation usually known to be involved in familial PD forms will be linked also to the sporadic cases, as for example leucine-rich repeat kinase 2 (LRRK2) that was found to regulate microRNA-mediated translation regulation. In addition postmortem microarray findings of transcription alterations will be compared to the peripheral findings of mRNA profiles. Molecular processes involved in ubiquitination and proteasome, autophagy, mitochondrial dysfunction and the nicotinic and adenosine A2 protection will be discussed. The question of what time-point should be taken measuring the different markers and the course of the disease will be mentioned, and the future possibilities in exploring these techniques will be debated.
Key Words: Parkinson\'s disease, transcription, microRNA, diagnose, marker