12th European AIDS Conference / EACS
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Proportion and trend over calendar time of patients with a low CD4 count or AIDS diagnosis at the time of their first contact with clinical care in Italy

Prof. Antonella d'Arminio Monforte
Prof. Antonella d'Arminio Monforte
Italy  
15 slide(s) – 00:07:14 – English – 2009-11-13
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To evaluate the frequency of patients presenting late to care within the Icona Foundation Study cohort and toe valuate their long term risk of death
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The frequency of late presenters (LP) in the Icona cohort, according to differnt definitions, and their outcome was investigated. More than 60% of patients entered the cohort with CD4 <350,and 43% with CD4<=200/cmm or AIDS.Late presenters are more likely to be non-Italian, older, by homosexual route, and to have higher viral load than the average patients diagnosed around the time of inclusion in the cohort. Patients presenting late showed increased long-term risk of death compared to patients diagnosed early; patients with AIDS at HIV diagnosis were those at higher risk of death.
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1- Nunez M, Ascencio R, Vaencia ME, Leal M, Gonzalez-Lahoz J, Soriano V: Rates, causes and clinical implications of presenting with low CD4 cell counts in te era of highly active antiretroviral therapy. AIDS Res Hum Retrovir 2003; 19: 363-368.
2- Girardi E, Aloisi MS, Arici C, Pezzotti P, Serraino D, Balzano R, Vigevani GM, Alberici F, Ursitti M, D'Alessandro M, d’Arminio Monforte A, Ippolito G for the I.CO.N.A. Study Group: Delayed presentation and late testing for HIV: demographic and behavioural risk factors in a multicenter study in Italy. J Acquir Immune Defic Syndr 2004; 36:951-959.
3- Kaufmann GR, Perrin L, Pantaleo G, et al. CD4 T-lymphocyte recovery in individuals with advanced HIV-1 infection receiving potent antiretroviral therapy for 4 years: the Swiss HIV cohort Study. Arch Intern Med 2003;163:2187-95.
4- Marks G, Crepaz N, Janssen RS. Estimating sexual transmission of HIV from persons aware and unaware that they are infected with the virus in the USA. AIDS. 2006 Jun 26;20(10):1447-50.
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