Parkinson's disease beyond 10 years
35 slide(s) – 00:30:36– English –2010-09-26
Parkinson’s disease (PD) is a chronic disease with progressive disability. It has been typically categorised in early and advanced stage according to the severity of motor symptoms, the overall benefit from antiparkinsonian drugs, and the emergence of drug-induced motor complications. Data on the clinical characteristics of the more advanced disease stages are more limited. Patient cohorts with more than 10 years disease duration have presented a high frequency of non-motor symptoms like sleep disorders, autonomic failure and dementia. However, a recent study on late-stage PD patients has questioned the inevitability of dementia. In late-stage PD, non-motor symptoms may dominate the clinical picture and have a significant impact on disability, appearing as the strongest independent predictors of nursing home placement. Very advanced PD patients will represent an important burden for families and the healthcare system.A prerequisite for the development of effective interventions (pharmacological and nonpharmacological) for these most advanced stages is the better characterization of its phenomenology. Social interventions should be included in the list of potential therapeutic interventions for which there is a need to produce robust data on effectiveness.