Parkinson’s disease (PD) is a chronic disease with progressive disability. It has been typically categorised in early and advanced stage according to the severity of motor symptoms, the overall benefit from antiparkinsonian drugs, and the emergence of drug-induced motor...(more)
Involvement of peripheral nerves by chronicMycobacterium leprae infection is the most characteristic manifestation of leprosy (Hansen’s disease). Leprosy constitutes an important public health problem in the developing world. The most likely portal of entry ofM. leprae is...(more)
Lyme disease is a systemic infection due to the tick-borne spirocheta Borrelia burgdorferi associated with musculoskeletal, neurological and cardiacmanifestations. It is endemic in the northeast, upper Midwest and northern California and Oregon of the United States as well...(more)
Background: In the last years, a growing body of literature indicates that seizures of women with epilepsy are influenced by reproductive state. It appears that steroid hormones, in particular oestrogen and progesterone, may have an effect on brain excitability, and,...(more)
Reproductive endocrine disorders are common among people with epilepsy. In women, menstrual disorders, polycystic ovaries, and infertility have been described, and in men, reduced potency and sperm abnormalities have been found. The reasons for this are multifactorial,...(more)
Sexuality is an important and private aspect of life and sexuality and epilepsy have been intimately linked since ancient time. In the modern medical era of epilepsy Gastaut and Collomb published that many patients with complex partial seizures have an apparent lack of...(more)
In about 80% stroke is caused by ischemia, i. e. critical reduction of cerebral blood flow (CBF) to the brain mostly as a result of thrombotic or embolic occlusion of supplying arteries leading to lack of oxygen and metabolic substrates in the tissue. The sudden decrease of...(more)
Critically ill patients may suffer from acute myopathy and neuropathy acquired during their intensive care unit (ICU) stay. These neuromuscular complications are indicated as critical illness myopathy (CIM) and critical illness polyneuropathy (CIP). CIP is an axonal...(more)
Gliomas, which are differentiated by morphological criteria defined in theWHO classification, are also characterized by distinct molecular alterations. Mutations of p53 and the isocitrate dehydrogenase (IDH) 1/2 genes are more common in gliomas ofWHO grades I-III whereas...(more)
- better understand the natural history of low-grade gliomas and glioblastomas
- know the oncological role of surgical resection in the treatment of gliomas
- know the functional contribution of surgery performed with cerebral mapping
- better understand the mechanisms of brain plasticity
Many causes of dementia, as well as other syndromes of cognitive impairment, can mimic the clinical state of dementia. Differentiating among these causes is important because of potential differences in symptom management and prognosis. Identifying causes of dementia more...(more)
Intense multidisciplinary research has provided detailed knowledge of the molecular pathogenesis of Alzheimer’s disease (AD). This knowledge has been translated into new therapeutic strategies with putative disease-modifying effects. Several of the most promising...(more)
Background: Cladribine is a purine analogue that is resistant to breakdown by adenosine deaminase. Cladribine is phosphorylated inside cells to the active compound 2-chloro-2'-deoxy-B-D-adenosine triphosphate (2-CdATP), which is preferentially activated in T and B...(more)
Pathophysiological considerations on non-convulsive status epilepticus (NCSE) have to reflect that neuronal networks generating generalised absence SE are completely different from those underlying simple- or complex-partial SE. Whereas thalamocortical neuronal populations...(more)
Cognition is regulated across the 24-h sleep-wake cycle by circadian rhythmicity and sleep homeostasis. To better understand these mechanisms, we used functional neuroimaging (PET, fMRI, EEG/fMRI) both during wakefulness and sleep in normal human volunteers.
In a first set...(more)
This lecture will focus on autonomic causes of orthostatic intolerance, where a variety of manifestations occur while changing position from recumbency to standing upright. The various symptoms will be described; they usually resolve readily on return to the horizontal...(more)
Transient ischaemic attack (TIA) is the sudden onset of focal neurological dysfunction of presumed vascular origin that, by definition, resolves within 24 hours (usually much sooner). Its importance as a predictor of completed stroke has only recently been recognised. The...(more)
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