12th Congress of the European Hematology Association
Prof. J. Duyster

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Biography
München, Germany  
Technischen Universität München

Biography
Univ.-Prof Dr. Justus Duyster
Klinikum rechts der Isar
Technical University of Munich

Medical studies in Freiburg.
Appointments:
University of Freiburg 1989–1992.
UCSD San Diego USA 1992–1994.
Max-Delbrück-Center for molecular Medicine Berlin 1994–1996.
Universiy of Ulm 1996–1998.
Technical University of Munich since 1998.

Currently Professor of Medicine and Experimental Hematology at the Dept. of Internal Medicine III, Technical University of Munich.

Scientific interests include signal transduction of oncogenic tyrosine kinases in hematology and solid tumors, preclinical and clinical development of molecular therapies for malignant diseases, mechanisms of resistance to signal transduction inhibitors and cell cycle regulation in malignant cells.


5 selected publications:

Miething, C., Grundler, R., Mugler, C., Brero, S., Hoepfl, J., Geigl, J., Speicher, M.R., Ottmann, O., Peschel, C., and Duyster, J. (2007). Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment. PNAS 104, 4594-4599.

von Bubnoff, N., Manley, P. W., Mestan, J., Sanger, J., Peschel, C., and Duyster, J. (2006). Bcr-Abl resistance screening predicts a limited spectrum of point mutations to be associated with clinical resistance to the Abl kinase inhibitor nilotinib (AMN107). Blood 108, 1328-1333.

Bassermann F, von Klitzing C, Munch S, Bai RY, Kawaguchi H, Morris SW, Peschel C, Duyster J. Nipa defines a novel SCF-type mammalian E3 ligase that regulates mitotic entry. Cell 122: 45-57 (2005)
Von Bubnoff N, Schneller F, Peschel C, Duyster J. Bcr-Abl gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. Lancet 259: 487-491 (2002)
Bai RY, Koester C, Ouyang T, Hahn SA, Hammerschmidt M, Peschel C, Duyster J. SMIF, a Smad-4 interacting protein that functions as a co-activator in TGFbeta signalling. Nature Cell Biol 4: 181-190 (2002)


Presentations by Prof. J. Duyster currently available on MultiWebcast.com
12th Congress of the European Hematology Association

Clinical implications of ABL mutational screening
2007-06-08 - English - Chronic Myeloid Leukemia