Detection of aberrations in haemostasis relies on screening assays that cover the different compartments of the haemostatic process. For screening primary haemostatic abnormalities the bleeding time is traditionally most widely performed. Due to its many disadvantages of...(more)
Major causes of morbidity and mortality in polycythemia vera (PV) and essential thrombocythemia (ET) are represented by thrombosis, bleeding, progression to myelofibrosis and transformation to acute leukemia. Myelosuppressive therapy, preferentially with hydroxyurea, can...(more)
The BCR-ABL negative chronic myeloproliferative disorders (MPDs) of essential thrombocythemia, polycythemia vera and primary myelofibrosis have an increasing predisposition to transforming to overt acute leukemia or MPD-Blast Phase (MPD-BP). The development of MPD-BP is...(more)
- the diagnostic tests used to identify patients with high-risk and low-risk multiple myeloma
- the clinical significance of genetic abnormalities for the treatment approach in multiple myeloma
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