INTRODUCTION: Schizophrenia is a disorder with chronic course and need for long-time treatment with antipsychotics to prevent relapses and rehospitalizations.
Objectives: To find possible association between treatment with different type of antipsychotics and rate of rehospitalizations in patients with schizophrenia spectrum disorders. AIMS: To analyze the rate of rehospitalizations during one year in groups of patients treated with typical, atypical and depot antipsychotics. METHODS: Data about 1400 patients discharged from hospitalization in 2010 with diagnostic code F20.x where obtained from General Health Insurance Company which covers majority of the population with chronic mental disorders in Slovakia. The structure of patients according to the age and sex represented the whole adult population hospitalized for diagnoses F20.x in Slovakia. RESULTS: 27.4 % of patients had 1 to 8 readmissions after the index discharge from hospitalization in the same year. 29347 prescriptions of psychopharmacological drugs were registered for 499886 patient/days in outpatient settings. 14781 prescriptions for antipsychotics consisted of 67.3 % prescriptions for p.o. atypical antipsychotics, 16.9 % for p.o. typical antipsychotics, 11.5 % for atypical depots and 4.2 % prescriptions for typical depots. No statistical significant association between the prescriptions of particular group of antipsychotics (typical, atypical, depot) and the occurrence of at least one rehospitalizations was found. CONCLUSIONS: No association between prescription of type of antipsychotics and probability for rehospitalization based on analyses of prescriptions rate could not reflect the clinical reality properly. Further analyses with consideration of dosage, combinations of antipsychotics and rate of prescriptions for individual patient should be done.
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