Dopamine dysregulation syndrome is a complication of the dopaminergic treatment for Parkinson’s disease, probably related to sensitization of the mesolimbic system. The relationship between dopamine dysregulation syndrome and deep brain stimulation of the subthalamic nucleus remains unclear. We report three patients with Parkinson’s disease who developed dopamine dysregulation syndrome for the first time after deep brain stimulation of the subthalamic nucleus. In our experience, the outcome of postoperative dopamine dysregulation syndrome is poor despite deep brain stimulation adjustments, attempts to reduce the dose of dopaminergic drugs and the addition of quetiapine or antidepressants
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