Abnormal brain iron levels are seen in Parkinson\'s disease (PD). To assess iron accumulation in different brain regions, 11 patients with hypokinetic-rigid PD and 11 healthy controls underwent MRI of the brain. Brain iron was quantified on a 3-tesla system by measuring R2, R2*, and R2’ relaxation rates. Motor symptoms were rated using UPDRS scores. In PD, iron was shown to accumulate in substantia nigra pars compacta (SNc) contralaterally to the clinically most affected side. Contralateral frontal white matter iron content was slightly decreased, and ipsilateral cerebellar iron content slightly increased in PD patients. Iron content of contralateral medial SNc correlated positively with UPDRS motor scores. Ipsilateral cerebellum iron content increased with disease duration.
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