Duloxetine's short-term modest influences in subcortical structures of first episode drug-naive patients with major depressive disorder and panic disorder
Dr. Chien-Han Lai
7 slide(s) – English – 2011-09-10
Objective: We developed this study to follow up the changes of subcortical structures after 6 weeks’ therapy of duloxetine in first episode drug-naïve patients with major depressive disorder and panic disorder. Methods: 15 patients received duloxetine 60 mg/d therapy for 6 weeks and achieved remission. They all received structural magnetic resonance imaging (MRI) of brain at baseline and 6th week. 15 healthy controls were also scanned twice at baseline and 6th week to exclude the possible biases. Structural MRI data was preprocessing with FMRIB\'s Integrated Registration and Segmentation Tool function (FIRST version 1.2) of FSL (FMRIB Software Library; version 4.1.1) to perform subcortical segmentations of brain by using shape and appearance model. The nonparametric corrections of these structural volumes in F test between pre- and post-treatment were used to identify the changes after duloxetine’s therapy. A false discovery correction of F test by FIRST was also performed. The paired t test using SPSS was applied to confirm the changes of these structures. Results: These patients had consistent changes of volumes in bilateral nucleus accumbens, left putamen, left hippocampus and brainstem after 6 week’s therapy of duloxetine. There were no consistent changes in other subcortical structures. There were modest increases of the volumes of the above areas, which were not significant after false discovery correction by FIRST F test comparisons. The volumetric increases were correlated with responses of clinical symptoms. Conclusion: The results suggested that duloxetine possibly contributed to modest increases in several subcortical areas of these patients with remission.