Prevalence of the metabolic syndrome and cardiovascular risk assessment in postmenopausal women using the Framingham risk score
Peter Chedraui, Rogelio López-Cuevas, Ana M. Falquez, Gustavo S. Escobar, Faustino R. Pérez-López, Luis Hidalgo, Andrea Genazzani and Tommaso Simoncini
Background. The metabolic syndrome (METS) increases with age and after the menopause onset. Despite this, its link to increased cardiovascular risk (CVR) is still not completely clear.
Objective. To determine in postmenopausal women the METS prevalence and calculate their 10-year CVR using the Framingham Risk Score.
Method. Framingham Risk Score was assessed in 325 non HT using postmenopausal women, with intact uterus and 40 years and older. Socio-demographics, anthropometry, blood pressure and biochemistry measurements were also evaluated. METS diagnosis was performed using NCEP-ATP III criteria.
Results. Prevalence of the METS was 41.5% according to ATP-III criteria. Median 10 year CVR rate was two fold for women with the METS in comparison to non METS ones (p=0.0001). Among women with the METS, 10 year estimated probability of presenting a myocardial infarction was higher among those with hypertension (p=0.0001) and significantly increased for those presenting 3 or more diagnostic criteria, with a two fold plateau observed for 4 and 5 positive criteria.
Conclusion. Prevalence of the METS was high in this series. CVR Framingham score was higher among women with the METS and in relation to the number of diagnostic features.
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