THE HOMA-IR AND LIPID PROFILE IN RESPONSE TO ISOFLAVONES IN ELDERLY WOMEN WITH THE METABOLIC SYNDROME
Iran 
You need to have a Flash player to see the MULTIWEBCAST Viewer. Please click on the link below to download Flash Player.
Get Flash Player
14 slide(s) – English – 2012-03-28
The HOMA-IR and lipid profile in response to isoflavones in elderly women with the metabolic syndrome
Afsaneh Bakhtiaria,b , Hanachi Parichehr c, Zaitun Yassina, , Asmah Rahmatd
a Institute of Gerontology, University Putra Malaysia, Serdang, Selangor, Malaysia.
b Women Department, Faculty of Medicine, Babol University of Medical Sciences, Iran.
c Faculty of Basic Science, Department of Biology, Biochemistry unite, Alzahra University Tehran, Iran.
d Nutrition & Dietetics Department, Faculty of Medicine & Health Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia.
To ascertain the effects of soy [in the form of textured soy protein (TSP) and soy-nut] on glycemic control and lipid profile in elderly women with metabolic syndrome. A 12-week randomized clinical trial was conducted on 75 women between 60-70 years of age with metabolic syndrome in rural health clinics around Babol, Iran in 2009. The participants were randomly assigned to one of the three groups of soy-nut (35g/d), TSP (35g/d) and control. Measurements were obtained before and after intervention, include, fasting blood glucose(FBG), insulin, HOMA-IR, lipids profiles, ApoB100 and ApoAI.
The soy-nut improved significantly FBG, insulin, HOMA-IR (P<0.05), while consumption of TSP established a significant decrease in serum insulin compared to the control group (p<0.04). Comparison of mean changes showed significant differences in mean changes of all of glucose control parameters in the treatment groups to the control group (p<0.001). On lipid profile, soy-nut also improved significantly LDL-C,VLDL-C and ApoB100 while fewer improvements but significant were observed in these variables by TSP, only when compared with the mean changes from the baseline. Similar result was found for ApoAI in the treatment groups. Both kinds of soy improved glycemic control and lipid profile, but a closer look shows that the soy-nut contributed more effectively than TSP. Therefore, it can be claimed that a moderate daily intake of soy may be a safe, cheap and practical way for the simultaneous improvement of insulin resistance and cardiovascular risk in elderly women with metabolic syndrome.
Keywords: glycemic control, lipid profile, soy, elderly
|
|
