The postoperative analgesic properties of intrathecal 2 µg and 4 µg dexmedetomidine combined with hyperbaric bupivacaine and its effects on the spinal anaesthesia
5 slide(s) – English – 2011-09-08
Objective: This study is designed to compare the postoperative analgesic properties, spinal anesthetic effects and side-effects of different doses of intrathecal dexmedetomidine added to hyperbaric bupivacaine during spinal anaesthesia.
Method: After obtaining the approval of the local ethical committee, 60 ASA-I group male patients who would undergo inguinal and perianal surgery were included in the study. I gained consent from every single patient. Patients were randomized into 3 groups of 20 people. The patients of Group-1 were administered with 3 ml hyperbaric bupivacaine + 0.5 serum physiological; the patients of Group-2 were administered with 3 ml hyperbaric bupivacaine + 2 µg dexmedetomidine; the patients of Group-3 were administered with 3 ml hyperbaric bupivacaine + 4 µg dexmedetomidine; each intrathecal, in a total volume of 3.5 ml. The effects on the spinal anaesthesia, time to the first pain and side effects were recorded. The side effects were appropriately treated. 8 mg larnoxicam was administrated intramuscularly when the pain started.
Findings: The demographic characteristics of the patients were found to be similar. The time to the first pain in Group-3 was observed to be significantly longer as compared to the Group-1 and Group-2. (p ˂ .0,05) The time to the first pain in groups were lined up from the shortest to the longest as: Group-1< Group-2< Group-3. In Group-1 the time to the first pain was 220.75±30 minute, in Group-2 the time to the first pain was 371.5±32 minute and in the Group-3 no analgesic was required.
Conclusion: The duration and efficacy of the multimodal analgesia performed by the use of different doses of dexmedetomidine, an adjuvant agent producing analgesia by the α2 agonistic mechanism of action, increases with the increasing dose of dexmedetomidine; and therefore the use of post-operative analgesic use decreases.