THE BURDEN OF ROTAVIRUS DISEASE IN DENMARK 2009-2010
Mr. Claus Sixtus Jensen
Denmark 
7 slide(s) – English – 2011-06-07
The Burden of Rotavirus Disease in Denmark 2009–2010
Background: This study sought to determine the incidence and the burden of severe diarrheal disease in Denmark with emphasis on rotavirus disease.
Methods: This study was designed as a national prospective disease surveillance of children <5 years of age hospitalized for acute gastroenteritis in Denmark during March 2009 to April 2010, using rapid rotavirus and adenovirus antigen detection.
Results: A total of 3100 hospitalizations annually among Danish children < 5 years can be attributed to acute gastroenteritis and 1210 (39%) of these to rotavirus disease. The majority of RV-associated hospitalizations occur among children < 24 months of age (RV-associated hospitalization rate: 7.7/1000 children< 24 months-of-age and 3.8/1000 children<5 years-of-age). Although the well-known seasonal pattern of rotavirus was evident with a peak during the spring months of March to April, our active surveillance demonstrated RV-associated hospitalizations throughout the year. Genotyping of a subset of RV-samples demonstrated high frequency of G1 (39%) and G4 (32%). Adenovirus was detected in 350 AGE-associated hospitalizations (11.2%).
Conclusion: In conclusion, of the 3100 annual AGE-associated hospitalizations among Danish children < 5 years, 1200 are RV-associated (39%). Rotavirus is indeed ubiquitous in the population; despite a marked seasonality it is associated with hospitalizations year round and can be considered a major health burden among young Danish children.
Authors: Thea K Fischer,1 MD, DMSc, Christine Rungoe,2 MD, Claus Sixtus Jensen,3 MHSc(Nurs), Morten Breindahl,4 MD, PhD, Jens-Peter Nielsen,5 MD, Lise Jensen6, MD, Michelle Malon,7 MD, Vagn Brændholt,8 MD, and Karsten Hjelt,9 MD, DMSc
Investigator group: Maren Rytter,10 MD, Louise Tram,11 MD, Inger-Marie Friis Ϯ,12 MD, Jes Reinholt,13 MD, Jens Veirum,14 MD, PhD, Klaus Johansen15 MD, Anders Johansen16 MD, Nana Trane,17 MD, Tine Rikke Jørgensen,18 MSc, MPH, Ann-Beth Rosenvinge19, MD, PhD
Affiliations authors: 1Department of Global Health, University of Copenhagen, 2Pediatric Department, Gentofte, University Hospital, 3Pediatric department, Skejby University Hospital, 4Pediatric department, Hilleroed Hospital, 5Pediatric department, Viborg Hospital, 6Pediatric Clinic II, Rigshospitalet University Hospital, 7Pediatric department, Holbæk Hospital, 8Pediatric department, Naestved Hospital, 9Pediatric department, Glostrup Hospital
Affiliations Investigator group: 10Pediatric Department, Gentofte, University Hospital, 11Pediatric department, Randers Hospital, 12Pediatric department, Hjoerring Hospital, 13Neonatal intensive Care Unit, University Rigshospital, 14Pediatric department, Skejby University Hospital, 15 Pediatric department, Sønderborg Hospital 16Pediatric department, Randers Hospital,17 Pediatric department Herning Hospital, 18Sanofi Pasteur, Lyngby, 19Neonatal Care Unit, Glostrup Hospital.
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