HOW DO HAEMOSTATIC VARIABLES AFFECT THROMBIN GENERATION DURING THE COURSE OF THE MENSTRUAL CYCLE?
Dr. Roza Chaireti
Sweden 
You need to have a Flash player to see the MULTIWEBCAST Viewer. Please click on the link below to download Flash Player.
Get Flash Player
10 slide(s) – English – 2012-06-29
HOW DO HAEMOSTATIC VARIABLES AFFECT THROMBIN GENERATION DURING THE COURSE OF THE MENSTRUAL CYCLE?
R. Chaireti 1,3, K. Bremme 2, K. M. Gustafsson 3, T. L. Lindahl 3
1 Department of Acute Internal Medicine, Acute Medicine and Coagulation Unit, Linköping University Hospital, Linköping
2 Department of Women`s and Children´s Health, Division of Obstetrics and Gynecology , Karolinska Institutet, Stockholm
3 Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Background and objectives: The data on thrombin generation (TG) variations during the menstrual cycle are scarce and mainly surrogate markers, such as thrombin-antithrombin complex (TAT) and prothrombin fragment 1+2 (F1+2) have been employed. This study aims at the effect of selected haemostatic variables on thrombin generation measured in real time during the follicular and the luteal phase of a normal menstrual cycle.
Subjects and Methods: The study cohort consisted of 102 healthy women who were not taking any form of hormone medication. TG was measured by the Calibrated Automated Thrombogram (CAT®) and the markers analyzed were lagtime (min), Endogenous Thrombin Potential (ETP, nmolar*min), peak thrombin (nmolar) and time to peak (ttpeak, min). We obtained full TG profiles (for both phases) for 73 subjects. The haemostatic variables analyzed were factor II (FII), factor VII (FVII), factor VIII (FVIII), antithrombin (AT) factor X (FX), D-dimer, von Willebrand factor (VWF) and fibrinogen. We used correlation analysis and simple regression analysis in order to evaluate our data.
Results: The correlations between TG and haemostatic variables during both phases were very weak. The factors that affected TG to some extend during the follicular phase were FVII, AT and VWF. FVII affected the ‘concentration’ (ETP, peak) and AT the ‘time’ parameters (lagtime, ttpeak). FVIII had the strongest effect on TG during the luteal phase.
Conclusion: Our results demonstrate that the effect of different haemostatic parameters on TG varies during the menstrual cycle and that TG markers that express ‘concentration’ or ‘time’ are influenced by different variables. Those findings contribute new data to the ongoing debate on which coagulation parameters affect TG the most and in which way.
|
|
