DO HAEMOSTATIC PARAMETERS VARY DURING THE COURSE OF THE MENSTRUAL CYCLE?
Dr. Roza Chaireti
Sweden 
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8 slide(s) – English – 2012-06-29
DO HAEMOSTATIC PARAMETERS VARY DURING THE COURSE OF THE MENSTRUAL CYCLE? R. Chaireti 1,*, K. Bremme 2, K. M. Gustafsson 3, T. L. Lindahl 3
1Department of Acute Internal Medicine, Acute Medicine and Coagulation Unit, Linköping University Hospital, Linköping, Sweden
2 Department of Women`s and Children ́s Health, Division of Obstetrics and Gynecology , Karolinska Institutet, Stockholm, Sweden
3 Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden
Background and Objectives: Many studies have been designed to evaluate the fluctuations of coagulation parameters during the menstrual cycle and have produced diverse results. This abstract reports our findings from the measurements of selected haemostatic variables during the follicular and luteal phase of a normal menstrual cycle.
Subjects and Methods: The study cohort consisted of 102 healthy women who were not taking any form of hormone medication.Blood samples were collected in the follicular phase of the menstrual cycle (cd 3-5) and in the luteal phase (cd 22-25). The haemostatic variables analyzed were factor II (FII), factor VII (FVII), factor VIII (FVIII), factor X (FX), D-dimer, von Willebrand factor (VWF), antithrombin (AT), tissue factor pathway inhibitor (TFPI, samples were measured by two different methods due to technicalities) and fibrinogen. As the number of observations (n) was greater than 30, we used the paired t-test (p<0,05, CI 95%) to evaluate our data.
Results: It was shown that FX (p=0,028) and TFPI (p=0,032,with p=0,037 and p=0,014 respectively for the two methods) were higher during the follicular phase. The levels of FVII and D-dimer were also somewhat higher during the follicular phase (p=0,09 and p=0,067 respectively).
Conclusion: Our results demonstrate higher pro- and anticoagulant potential during the follicular phase. Those results cannot be explained by the effect of high hormone concentrations, as both progesterone and oestradiol are low during this phase. Residual fibrinolytic effect following menstruation can possibly explain the higher fibrinolysis markers. More studies are required in order to explain those variations.
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