Normal pregnancy is associated with hypercoagulable state and activation of fibrinolysis. It is important to establish normal deviations of D-dimer, f. XII levels and XIIa-dependent fibrinolysis for physiological pregnancy.
The citrate plasmas of 117 healthy pregnant women at the age from 19 to 40 years were evaluated. D-dimer level and factor XII activity were significantly increased during normal pregnancy. XIIa-dependent fibrinolysis had statistically prolongation only in III trimester.
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